Fri Oct 06 2023

43 articles - From Friday Sep 29 2023 to Friday Oct 06 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Am J Clin Nutr

Inter-individual differences in children's short term energy compensation: a systematic review and meta-analysis.

The systematic review highlighted wide variability across studies, while the meta-analysis demonstrated differences in COMPx by child weight status but not by age or sex. Standardizing protocols across studies is recommended, along with designing adequately powered studies aiming a priori to test inter-individual differences . Alternative approaches to the use of COMPx are recommended to allow better characterization of children's energy compensation ability. Registry Registered on PROSPERO CRD42020197748.

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J Crohns Colitis

Patient Reported Outcome Measures in Ileoanal Pouch Surgery: a Systematic Review.

Only half of the papers reviewed used PROMs. The main reported item is bowel function, whilst urogenital, social, and psychological function are the most neglected. There is lack of standardisation for use of PROMs in IPAA. Complexity of UC and of outcomes after IPAA demands a change in clinical practice and follow up given how crucial PROMs are, compared to their non-routinary use.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia.

Greater growth between 0-6 years of development was positively associated with kidney size and greater growth velocity after 2 years was associated with higher serum cystatin C level.

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Changes in Coffee Intake, Added Sugar and Long-Term Weight Gain - Results from Three Large Prospective US Cohort Studies.

An increase in intake of unsweetened caffeinated and decaffeinated coffee was inversely associated with weight gain. The addition of sugar to coffee counteracted coffee's benefit for possible weight management. On the other hand, adding cream or coffee whitener were not associated with greater weight gain.

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Egg consumption and risk of coronary artery disease, potential amplification by high genetic susceptibility: a prospective cohort study.

Genetic predisposition may synergistically interact with egg consumption in relation to increased CAD risk. PRS-stratified recommendations on egg consumption may help formulate personalized nutrition policies.

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Omega-6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies.

Biomarkers of n-6 fatty acids including LA and AA were not associated with incident AF. These findings suggest that overall effects of n-6 PUFAs on influencing AF development are neutral.

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Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study.

Increased glutamic acid, aspartic acid, and gamma-aminobutyric acid and decreased glycine in plasma are associated with adverse outcomes after ischemic stroke, suggesting that plasma amino acid neurotransmitters may be potential intervention targets for improving prognosis of ischemic stroke. The CATIS trial was registered at clinicaltrials.gov (registration number NCT01840072; URL ===

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Types of Dairy Foods and Risk of Fragility Fracture in the Prospective Nurses' Health Study Cohort.

Higher total dairy, milk and cheese intakes were associated with lower risks of fracture in females in NHS.

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Inflamm Bowel Dis

Appearance of the Bowel and Mesentery During Surgery Is Not Predictive of Postoperative Recurrence After Ileocecal Resection for Crohn's Disease: A Prospective Monocentric Study.

The macroscopic appearance of the bowel and associated mesentery during surgery does not seem to be predictive of POR after ileocecal resection for CD.

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KONO-S Anastomosis Is Not Superior to Conventional Anastomosis for the Reduction of Postoperative Endoscopic Recurrence in Crohn's Disease.

Kono-S anastomosis was not associated with a reduced rate of endoscopic POR. These results warrant confirmation in prospective, randomized, multicenter studies.

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Outcome of Very Early Onset Inflammatory Bowel Disease Associated With Primary Sclerosing Cholangitis: A Multicenter Study From the Pediatric IBD Porto Group of ESPGHAN.

Primary sclerosing cholangitis related to inflammatory bowel disease has similar baseline characteristics whether diagnosed as VEO-IBD or thereafter. A milder disease course in terms of biliary complications characterizes VEO-PSC-IBD.

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The Efficacy of an Over-the-Counter Multivitamin and Mineral Supplement to Prevent Infections in Patients With Inflammatory Bowel Disease in Remission With Immunomodulators and/or Biological Agents: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

An over-the-counter multivitamin and mineral supplement did not reduce the risk of infection for patients with IBD in remission with immunomodulators, biologic therapy, or combination therapy.

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J Crohns Colitis

Baseline expression of immune gene modules in blood is associated with primary response to anti-TNF therapy in Crohn's disease patients.

Baseline gene module expression was associated with primary response to anti-TNF therapy in PANTS patients. However, these baseline expression differences did not predict response with sufficient sensitivity for clinical use.

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HLA signatures as pathophysiological discriminants of microscopic colitis subtypes.

Our results suggest CC and LC have distinct pathophysiological underpinnings, characterised by an HLA predisposing role only in CC. This challenges existing classifications, eventually calling for a re-evaluation of the utility of MC umbrella definitions.

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Maintenance Risankizumab Sustains Induction Response in Patients with Crohn's Disease in a Randomized Phase 3 Trial.

Subcutaneous risankizumab maintenance therapy results in durable improvement in clinical and endoscopic outcomes over 1 year in patients with moderately to severely active Crohn's disease.

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Submucosal injection of the RNA oligonucleotide GUT-1 in active ulcerative colitis patients: A randomized, double-blind, placebo-controlled phase 2a induction trial.

Single dosing by submucosal injection of GUT-1 repressed CHST15 mucosal expression and may represent a novel induction therapy by modulating tissue remodeling in UC.

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Tofacitinib for patients with anti-TNF refractory ulcerative proctitis: a multicenter cohort study from the GETAID.

Tofacitinib may offer a therapeutic option for patients with refractory UP.

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Liver Transpl

Autoimmune hepatitis recurrence after liver transplantation: "Les jeux sont faits".

Recurrence of AIH after LT is frequent and may lead to graft loss. Recurrence is more frequent in young patients with active disease at the time of LT, yet systematic corticosteroid therapy does not prevent it.

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Outcomes of living donor liver transplant recipients receiving grafts with the Graft-to-Recipient weight ratio less than 0.6%: A matched pair analysis.

In conclusions, although similar overall graft survival rates were observed for LDLT with GRWR <0.6% and GRWR =0.6%, GRWR <0.6% was associated with an increased risk of SFSS. Appropriate donor and recipient selection is important for successful LDLT with very small grafts.

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Outcomes of re-referrals of patients with alcohol-related liver disease who were previously declined for liver transplantation.

Patients with ALD previously declined for liver transplant can be re-referred and successfully accepted for transplantation by fulfilling the recommendations made by the multidisciplinary team. Important factors including ongoing abstinence, engagement in addiction treatment and social support are key for successful acceptance.

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Pancreas

Current Situation and Problems in Diagnosis of Early Chronic Pancreatitis.

Early chronic pancreatitis diagnostic rate was low, particularly in nonalcoholic cases, but was slightly higher in cases with pancreatic pain. The diagnostic rate was highest in the abdominal/back pain group. Further studies are required to establish appropriate diagnostic criteria for ECP.

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Perioperative Chemotherapy and Chemoradiotherapy for Patients With Resectable and Borderline Resectable Pancreatic Adenocarcinoma.

Perioperative therapy with GTX, chemoradiotherapy, and adjuvant GemOx/Gem resulted in promising survival of 58 months for patients who underwent resection and may represent another treatment option for PDA.

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Response of Locally Advanced Pancreatic Cancer to Intratumoral Injection of Large Surface Area Microparticle Paclitaxel: Initial Report of Safety and Clinical Outcome.

Neoadjuvant IT LSAM-PTX, in combination with SOC, was well tolerated and may provide benefits to LAPC patients, evidenced by enhanced immune response, improved disease control rate, restaging leading to surgery, and extended survival.

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Pancreatology

Comparing fine needle biopsy techniques in solid pancreatic lesions: A prospective randomized study.

When performing EUS-FNB for solid pancreatic lesions located in the head/uncinated process, the three methods provided similar diagnostic yields. The wet-suction technique had a higher score in tissue integrity when lesions were located in the body and/or tail of the pancreas.

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European' health care indicators and pancreatic cancer incidence and mortality: A mediation analysis of Eurostat data and Global Burden of Disease Study 2019.

Health care environment correlates with reported incidence and mortality of pancreatic cancer. This highlights both that ameliorated socio-economic societies suffer from higher incidence but lower mortality, as well as the epidemiological bias originating from countries' diagnostic ability.

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Rectal administration of tacrolimus protects against post-ERCP pancreatitis in mice.

Our results underscore the effectiveness and clinical utility of rectal Tac for PEP prophylaxis.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Amino acid neurotransmitters and prognosis after stroke: nutrition as a modifiable factor to improve stroke outcomes.

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Genetic susceptibility modifies the association between egg consumption and coronary artery disease.

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Inflamm Bowel Dis

Disease Clearance is not Synonymous with Cure.

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Is Ulcerative Colitis Really Ever "Cleared?"

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J Crohns Colitis

Lémman Index in Children: Still an Open Question.

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Pancreatology

Pancreatic duct pressure: A review of technical aspects and clinical significance.

Ductal hypertension or increased PDP is suspected to be involved in the pathogenesis of pancreatic pain, endocrine and exocrine pancreatic insufficiency, and recurrent pancreatitis. This review provides a comprehensive appraisal of the available literature on PDP, including the methods used in the measurement and clinical implications of elevated PDP.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Postvaccination Symptoms After a Fourth Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease.

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Liver Transpl

Access and outcomes in liver transplant candidates: How and when we measure is as important as what we measure.

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Disparities in travel time to liver transplantation centers in the United States.

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Letter to the editor: The "one liver, one artery" approach for marginal grafts.

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Liver transplantation from uncontrolled DCD donors-is there light at the end of the tunnel?

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Living donor liver transplantation in the U.S. for alcohol-associated liver disease and non-alcoholic steatohepatitis: An evaluation in the current era.

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Pediatric sarcopenia: An imperfect science in evolution.

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Plasma exchange, a promising liver support system with still relevant uncertainties.

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Predicting cardiovascular events post-liver transplant: Is CT coronary angiography the noninvasive test we have been looking for?

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Sarcopenic obesity: A new predictor of recipient liver regeneration after living donor liver transplantation?

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

Unveiling the optimal soluble dietary fiber for type 2 diabetes: galactomannans take the lead?

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